Established in 2016 to advance economic and community prosperity in the Indiana Uplands region, Regional Opportunity Initiatives (ROI) is implementing an education and workforce plan and a regional opportunity fund for quality-of-place investments in an 11-county area. In 2016, Lilly Endowment Inc. awarded three grants totaling $42 million to ROI's
partner organizations to fund a number of regional development initiatives from the strategic plan.
The Southern Indiana Development Commission (SIDC) is a voluntary organization of local government. SIDC provides assistance with both community and economic development initiatives.
SIDC offers a wide variety of services including housing, transportation, brownfields and rural transit.
Radius Indiana is a regional partnership representing eight counties in Southwest Central. Radius Indiana also serves as a point of contact in Indiana for Naval Support Activity Crane and leads regional collaboration by leveraging its diverse assets to drive attraction, retention and expansion of business. As a result-driven regional leader in economic development they work to increase employment, investment and quality of life within the region. Greene County partners with Radius to establish new site locations, business expansion and business retention. Radius provides new or existing businesses with economic development support.